• 
  LDU Quito – Aucas

  23 April

• 
  Barcelona SC – Mushuc

  23 April

• 
  CD Cuenca – Orense

  22 April

• 
  Delfin – Independiente

  22 April

• 
  Leones Del Norte – Manta

  22 April

• 
  Tecnico Univ – Emelec

  22 April

• 
  Libertad – Guayaquil

  21 April

• 
  Burnley – Manchester

  22 April

• 
  Bournemouth – Leeds Utd

  22 April

• 
  Brighton – Chelsea

  21 April

• 
  PSG – Nantes

  22 April

• 
  Gamba Osaka – Avispa

  22 April

• 
  Fortaleza CEIF – America

  23 April

• 
  Ind Medellin – Boyaca

  23 April

• 
  Necaxa – Guadalajara

  23 April

• 
  Atletico San Luis – Santos

  23 April

• 
  Atlas – UANL

  23 April

• 
  Mazatlan – Toluca

  23 April

• 
  Leon – America

  22 April

• 
  Monterrey – Puebla

  22 April

• 
  Pumas – Juarez

  22 April

• 
  Queretaro – Cruz Azul

  22 April

• 
  Rubio Nu – Libertad

  21 April

• 
  Lokomotive M – Zenit

  22 April

• 
  Dynamo M – Rubin

  22 April

• 
  Orenburg – Nischni

  22 April

• 
  ZSKA – Rostow

  21 April

• 
  Sotschi – Krylja Sowetow

  21 April

• 
  Barcelona – Celta

  22 April

• 
  Real Sociedad – Getafe

  22 April

• 
  Elche – Atletico Madrid

  22 April

• 
  Girona – Real Betis

  21 April

• 
  Real Madrid – Alaves

  21 April

• 
  Mallorca – Valencia

  21 April

• 
  Athletic – Osasuna

  21 April

• 
  San Jose – Austin

  23 April

• 
  Los Angeles – Colorado

  23 April

• 
  Columbus Crew – LA

  23 April

• 
  Real Salt Lake – Inter

  23 April

• 
  Houston Dynamo – San

  23 April

• 
  Dallas – Minnesota Utd

  23 April

• 
  Atlanta Utd – New

  23 April

• 
  New – Cincinnati

  23 April

• 
  NY Red Bulls – DC United

  23 April

• 
  Toronto – Philadelphia

  23 April

• 
  Orlando City – Charlotte

  23 April

• 
  Bosna Royal – Dubai

  21 April

• 
  Siroki – TFT Skopje

  22 April

• 
  Al-Nasr – Al-Ahli Doha

  22 April

• 
  Machida Zelvia – Shabab

  21 April